The defending NFC champion San Francisco 49ers look to win at home for the second consecutive week as they host NFC West division rival, the Arizona Cardinals on Sunday afternoon. The Niners (2-2) beat the Patriots last week, 30-13, while the Cardinals (1-3) fell at home to the Commanders, 42-14. San Francisco has won four straight meetings between the two teams, having scored 38, 38, 35 and 45 points in their matchups against Arizona since the 2022 season.
Kickoff from Levi’s Stadium is set for 4:05 p.m. ET. San Francisco is a 7.5-point favorite in the latest 49ers vs. Cardinals odds, per SportsLine consensus, while the over/under for total points is 50. Before making any Cardinals vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-23 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Cardinals vs. 49ers and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for spread, money line and over/under:
- 49ers vs. Cardinals spread: 49ers -7
- 49ers vs. Cardinals over/under: 50 points
- 49ers vs. Cardinals money line: 49ers -357, Cardinals +281
- 49ers vs. Cardinals picks: See picks at SportsLine
- 49ers vs. Cardinals streaming: FuboTV (Try for free)
Why the Cardinals can cover
If Arizona is to play San Francisco close on Sunday, quarterback Kyler Murray needs to up his play from the past two weeks. In the team’s blowout loss to Washington, Murray completed 16 of 22 passes for only 142 yards and one touchdown. Though he had rushed for 50+ yards in each of his previous three games, he only had one attempt for three yards in Week 4. On the season, Murray is only averaging 194 yards passing per game, which likely will need to rise for his offense to find more success.
Wide receiver Marvin Harrison Jr., the No. 4 overall pick in April’s draft, has now caught a touchdown in three straight games for Arizona. On the season, he has 15 catches for 243 yards and four scores, numbers which Arizona would like to see rise significantly. Running back James Conner has topped 100 yards rushing twice and scored three times this season. Another big game from him would also boost Arizona’s chances. See which team to pick here.
Why the 49ers can cover
With 1,130 passing yards through four games, Brock Purdy ranks second in the NFL only behind Seattle’s Geno Smith. Despite the passing yards, San Francisco’s QB has only thrown for five touchdowns, a surprisingly low total after he threw for 31 scores in 2023. With likely a full complement of receiving weapons this week: wide receivers Brandon Aiyuk, Deebo Samuel and Jauan Jennings, as well as tight end George Kittle, Purdy should have no problem carving apart Arizona’s soft secondary.
Running back Jordan Mason has been a key part of San Francisco’s offense in the absence of reigning NFL Offensive Player of the Year, Christian McCaffrey. Mason has topped the 100 yard mark in three of four games and scored three times. He ranks second in rushing yards with 447 and faces a Cardinals defense giving up 146.5 yards per game on the ground (fifth worst). See which team to pick here.
How to make Cardinals vs. 49ers picks
The model has simulated Arizona vs. San Francisco 10,000 times and the results are in. It is leaning Over on the point total, and it also says one side of the spread hits well over 60% of the time. You can only see the model’s Cardinals vs. 49ers pick at SportsLine.
So who wins San Francisco vs. Arizona on Sunday, and which side of the spread hits well over 60% of the time? Visit SportsLine right now to see which side of the Cardinals vs. 49ers spread you should be all over Sunday, all from the model on a 188-131 roll on its top-rated NFL picks, and find out.
