The No. 11 USC Trojans (2-0) kick off a new era on Saturday when they play their first Big Ten conference game against the No. 18 Michigan Wolverines (2-1) at Michigan Stadium. The Trojans had a bye in Week 3, giving Lincoln Riley and his staff two weeks to prepare for this matchup. USC defeated Utah State 48-0 in its last outing. Michigan has had issues on the offensive side of the ball and will be turning to junior Alex Orji at quarterback. The Wolverines are coming off a 28-18 win over Arkansas State in Week 3.
Kickoff at Michigan Stadium in Ann Arbor is scheduled for 3:30 p.m. ET on CBS and Paramount+. The Trojans are favored by 4.5 points in the latest USC vs. Michigan odds via SportsLine consensus, while the over/under is 44 points. Before making any Michigan vs. USC picks, you need to see the Week 4 college football predictions and betting advice from SportsLine’s Jimmie Kaylor.
Saturday’s game can be seen live on CBS and streamed live on Paramount+, which you can now get for 50% off your first year plus a 7-day free trial (valid through 9/22/24). Sign up here and get half-off.
Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years.
Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.
Now, Kaylor has dialed in on Michigan vs. USC on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and betting lines on the spread, money line and over/under for USC vs. Michigan:
- USC vs. Michigan spread: USC -4.5
- USC vs. Michigan over/under: 44 points
- USC vs. Michigan money line: USC -190, Michigan +156
- USC vs. Michigan streaming: Paramount+
- USC vs. Michigan picks: See picks at SportsLine
Why USC can cover
USC has had two weeks to prepare for this marquee matchup. The Trojans notched an impressive win over LSU in their season opener, and followed that up with a dominant shutout win over Utah State a week later before having Week 3 off. Junior quarterback Miller Moss has been efficient and played turnover-free football in his first season as the program’s full-time starter.
Lincoln Riley-led teams have never been known as defensive juggernauts, but the 2024 Trojans may be different. New defensive coordinator D’Anton Lynn has completely changed the culture for USC on that side of the ball, and the results speak for themselves. The Trojans held LSU’s high-powered attack to 20 points and then shut out Utah State a week later. See which team to pick here.
Why Michigan can cover
Jim Harbaugh has moved on to the NFL, but Michigan remains one of the top defensive teams in college football. The Wolverines gave up 31 points to No. 1 Texas, but a lot of that can be attributed to three untimely turnovers from the team’s offense that put the defense in tough situations. Michigan allowed a total of 28 points in its other two games of the season.
The Wolverines are expected to go with Alex Orji at quarterback this week. Orji is unproven as a passer, but is an elite athlete, and his running ability will put a lot of pressure on USC’s defense. The Wolverines also have a two-headed monster at running back in Donovan Edwards and Kalel Mullings, and an All-American candidate at tight end in Colston Loveland, though he is questionable for an undisclosed injury. See which team to pick here.
How to make Michigan vs. USC picks
Kaylor has analyzed USC vs. Michigan from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.
So who wins Michigan vs. USC in Ann Arbor on Saturday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.
